Xue Shepu



Xue Shepu
Xue Shepu, cytobiologist, was from Xinhui, Guangdong Province. He graduated from the department of natural science in Chongqing Central University in 1943, got his master’s degree in biology at that school in 1947 and got his doctoral degree from Washington University (Saint Louis) in the US in 1951. He worked as researcher for the Institute of Basic Medical Sciences at Chinese Academy of Medical Sciences, professor of Chinese Peking Union Medical College. He provided some important theoretical support for the principle of cell differentiation and its manageability, and made a great contribution to the studies of male reproductive biology and the birth control medicine, gossypol. He created the cytosome hybrid model of reticulocyte and myeloma cell; he found the relationship between the inhibition of the genes of vimentin and the de-nucleation of the vimentin; he worked out the reason of the natural de-nucleation of mammal hematid and the double phase phenomenon of the de-nucleation; he first discovered the EDDF, something that can reverse the negative split within the mammal hematids, adjust gene expression and induce terminal differentiation. The purified active materials perform the active function of inhibiting growth and boost differentiation on the transferring of tumor cells. This EDDF clones the structure of the whole genetic sequence and code of the terminal related genes in different stages; he raised the theory of pyknosis and the new concept of curing cancer by ending the negative split of the tumor cells. He was elected as a committee member of the Chinese Academy of Sciences.





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